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What is cow's milk allergy ?
 
-  Cow’s milk allergy is an adverse immunological reaction to one or more of the proteins in cow’s milk1

-  Cow’s milk allergy is the most common childhood food allergy.2  It affects 2-7.5% of all infants1

-  On average, infants acquire tolerance to cow’s milk between 3-5 years of age3-5

-  Symptoms often start within the first few weeks of exposure to cow’s milk protein

-  Symptoms are diverse and could affect the gut, skin and/or respiratory systems.  
   Reactions can be acute or delayed1

 
-  Distressing symptoms and the constant need to avoid allergens can profoundly affect a family’s quality      of life6


Immunopathogenesis of cow’s milk allergy

Proteins in cow’s milk activate the infant’s immune system and with an allergy, it triggers inflammation and a variety of allergic symptoms.


 


Cow’s milk proteins can cause an inflammatory response in two ways:

IgE reaction

- Triggered by cross-linking of mast cell-bound IgE antibodies

- Usually an immediate reaction


Non IgE reaction

- Triggered by activation of antigen-specific T-cells
 
- Usually a delayed reaction
  1. Vandenplas 2007
  2. Skripak 2007
  3. Host 2002
  4. Santos 2010
  5. Canani 2013
  6. Cummings 2010
  7. Crittenden 2005
  8. DuToit 2010